Screening for Beta Thalassaemia Carriers: A Relook

نویسنده

  • Elizabeth George
چکیده

Thalasssaemia is an inherited disorder of haemoglobin synthesis. It is characterised by absence or reduced synthesis of one or more globin chains of human haemoglobin. Public health concern about carrier detection is not only confined to the geographical areas with high disease prevalence but becomes a global issue because of population migration [1]. The majority of carriers are not aware of their status. The homozygous state of β0-thalassaemia results in transfusion dependent thalassaemia.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Thalassaemia screening among students in a secondary school in Ampang, Malaysia.

Thalassaemia is a common disorder in Malaysia. It is estimated that 4.5% of the population are carriers for beta- or alpha- thalassaemias. We set out to screen Form 4 students aged between 15 and 16 years old in a national school, for thalassaemia in March 2008. Written consent was obtained from 310 students. The carrier rate for the common thalassaemia syndromes was 6.8% (2.9% for beta-thalass...

متن کامل

Premarital Screening of Beta Thalassemia Minor in north-east of Iran

Abstract Background Beta thalassemia is a preventable disease. Iran has about 20,000Patients who are homozygote for β-thalassaemia and 3,750,000 carriers. The aim of this study was to determine the prevalence of beta thalassemia minor among men who underwent premarital screening in Quchana city in Khorasan Razavi region of Iran Materials and Methods This research is a descriptive cross-sect...

متن کامل

A New Approach Based on Erythrocyte Indices to Exclude Normal Populations from Chromatography Based Thalassemia Screening Programs with Very High Fidelity

Background: Screening and counselling is the most effective way to prevent the birth of children with thalassemia major. An accurate and relatively less time-consuming protocol is necessary to screen large populations. Separating iron deficiency anaemia from thalassemia trait based on blood cell parameters has been used by hematologists for many years. We aimed to design a new approach to scree...

متن کامل

Why are thalassaemia patients born when prenatal screening is available?

Thalassaemia major is a classic example of a disease that is preventable by prenatal diagnosis. Although the technology was introduced to Hong Kong more than a decade ago, new patients are continuously seen in the Hong Kong Administrative Region. This retrospective review concerns children who were diagnosed to have severe beta-thalassaemic syndromes at the Tuen Mun Hospital from 1990 to 1996. ...

متن کامل

Prenatal diagnosis of beta-thalassaemia by chorionic villous sampling.

OBJECTIVE To establish intrauterine diagnosis of thalassaemia major in couples with thalassaemia trait by chorionic villous sampling. METHODS A total of 60 couples with children suffering from transfusion dependent beta-thalassaemia or couples who were known carriers of beta-thalassaemia were included in this study. The standard procedure was followed for the collection of samples which was f...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015